Flames broke out around 2:45 a.m. on the 2700 block of Bellview Drive in Bensalem, Pennsylvania.
Firefighters arrived to find heavy smoke and flames coming from the home.
Officials say a man was waiting outside, telling firefighters there was a woman trapped in the home.
Firefighters pulled her out from near the kitchen, but she was pronounced dead at the scene.
She has been identified as 56-year-old Christine Toal.
The man was taken to Jefferson Torresdale hospital for treatment.
His identity has not been released.
The cause of the fire remains under investigation.