Evidence markers were seen on the street, sidewalk and a porch on North 24th Street, by Cambria, as the Crime Scene Unit combed the area.
Officers were dispatched shortly before midnight. When they arrived, they found a man and a woman, both in their 60s, who had been shot.
The two shooting victims were rushed to Temple University Hospital, and investigators tell Action News the woman was pronounced dead a short time later.
The condition of the other victim was not immediately released.
No word yet from police on any arrests or what led up to the shooting.