The fire began at 1:00 a.m. Friday on the 5600 block of Bloyd Street.
Firefighters had difficulty gaining access to the home because the windows were heavily fortified.
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At one point flames shot 30 to 40 feet in the air.
It took firefighters about 45 minutes to get the fire under control.
A woman's body was later found inside the rubble. No word on her identity.
Investigators say the home was filled with debris and believe it was a case of hoarding.
The cause of the fire is under investigation.