Police were called to the 6300 block of Germantown Avenue just after 6 p.m.
Officers found the 48-year-old victim shot multiple times inside a bathroom.
She was pronounced dead at the scene.
So far, there are no motives or suspects.
Anyone with information can call or text Philadelphia police at 215-686-TIPS (8477) or submit an anonymous tip online.
RELATED: Check the 6abc Neighborhood Safety Tracker