It happened shortly after midnight Sunday at 200 block of West 20th Street.
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Police identified the female as Keshall (KeKe) Anderson.
She was taken to Christiana Hospital where she was pronounced dead.
The male was also taken to the hospital with non-life-threatening injuries.
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His name has not been released.
So far, no arrests have been made.
Anyone with information relative to this investigation is asked to call the Homicide Hotline at 302-576-3939.