Officers were called to the Quality Inn Hotel located on W. Landis Avenue around 1 p.m.
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According to the Cumberland County Prosecutor's Office, a 41-year-old woman was found shot to death inside a vehicle in the parking lot.
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Officers later located a 44-year-old man dead from what appears to be a self-inflicted gunshot wound.
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There was no immediate word on a motive for the shooting.
The man and woman have not been identified.