It happened around 11 a.m. on the unit block of Industrial Highway in Essington.
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Amber Hoyt said she was sleeping when she heard multiple gunshots and what sounded like glass breaking.
"Up on the second floor they were coming out with a guy on the ambulance. He was shot in both his legs," said Hoyt.
Police said the victim was living at the hotel after a house fire a few months ago.
According to investigators, a male suspect ran from the scene.
Police said the shooter then ditched the weapon in the parking lot of the Travelodge hotel next door, ran across I-95 and then jumped into Darby Creek.
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Police had to use a fire boat to get into the creek and get the suspect out.
Officials said the suspect was taken to the hospital but expected to be ok. The condition of the victim was not immediately known.
Multiple agencies responded to the incident.
The investigation is ongoing.