This happened at Ridley Dental Center on W. MacDade Boulevard at Morris Avenue.
Chopper 6 was over the scene where most of a tractor-trailer was at rest inside the building.
At least two other heavily damaged vehicles were nearby.
Chopper 6 over scene after truck hits building
Officials tell Action News only minor injuries have been reported.
The number of people injured was not immediately known.
The cause of the crash remains under investigation.