It happened shortly after 6 a.m. Friday on the northbound lanes of the Boulevard between Tyson and Cottman avenues.
Police say a pedestrian was fatally struck by a vehicle in the inner drive.
Chopper 6 over the scene showed police vehicles blocking traffic.
Action News is told the driver of the striking vehicle remained at the scene.
Police say the man who was struck is about 30 years old, but so far he remains unidentified.
The investigation is ongoing.