It happened around 1:30 a.m. on the southbound lanes of the boulevard extension near the Fox Street exit.
Police say a 24-year-old driver crashed into a utility pole and then the vehicle burst into flames.
Crews were able to pull him from the wreckage.
The driver was taken to the hospital with third-degree burns. He was listed in serious condition.
The roadway was closed for several hours as police were investigating.