It started around 5 a.m. at the Flannigan Auto and Truck Center on the 7500 block of Crescent Boulevard, Route 130.
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Crews arrived to find fire shooting through the roof of the building.
Chopper 6 over the scene showed portions of the building collapsed.
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Fire command reported there were several explosions.
There were no reports of any injuries, and investigators are on the scene trying to determine the cause.