It happened around 3 p.m. when Pennsylvania State Police say the driver of a tractor-trailer attempted to merge from a parked position on the westbound shoulder to the travel lane.
That's when the driver was hit by a commercial tanker truck, which overturned in the median, spilling liquid asphalt near Mingo Road.
Chopper 6 over scene of truck crash on Route 422
Authorities said the lanes had to be shut down for hazardous material cleanup. Emergency crews used sand to contain the spill.
The truck drivers were not seriously hurt.