It happened around 5:30 p.m. on Henry Avenue and Barnes Street.
Police say the 17-year-old boy was traveling eastbound on Barnes Street on his bike when he was struck by the driver. The teen died at the scene.
Witnesses say the victim was wearing his helmet at the time of the accident.
"It sounded like an explosion," said one neighbor who did not want to be identified.
Suzanne Hagner lives nearby and says she has lobbied for years to make this dangerous section of Henry Avenue safer.
The Streets Department recently installed lights and PennDOT is planning a project set to begin in 2021.
The project involves 4.7 miles of safety improvements along Henry Avenue through the communities of Roxborough and East Falls
"When the PennDOT project starts, we're going to get a raised median there which will slow people down. They're going to put in a bike trail, a pedestrian trail on the side. We're going to get a red-light camera," said Hagner.
No charges have been filed against the driver who did remain at the scene.
The victim has not yet been identified.