The crash happened around 3 p.m. Thursday on Washington Valley Road near Blossom Drive.
Officials say no children were on the bus at the time of the crash.
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NewsCopter 7 video showed the bus and a dark-colored SUV collided. A second vehicle was off the road a short distance from the accident scene and appeared to have been T-boned.
The driver of one of the vehicles remained trapped for more than an hour after the crash.
Three others in that vehicle were taken to the hospital, officials said.
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The extent of the injuries are not yet known.
The crash remains under investigation.
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