It happened around 5:30 p.m. Friday at the intersection of 5th and Berks streets.
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Police say the impact of the crash sent an overturned vehicle into the Route 3 SEPTA bus.
One person on that bus was hurt and two victims from the cars were injured.
It's not clear on which victim was taken by ambulance to the hospital.
The injuries appear to be non-life threatening.
There is no immediate word on what caused the crash.
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