It happened around 6 a.m. Friday at 5th Street and Allegheny Avenue.
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Police say the Route 47 bus collided with the truck, crashed into a utility pole and then came to a rest in a parking lot of a used car dealership. The bus also struck some of the used cars.
SEPTA says the passengers suffered non-life-threatening injuries.
The truck suffered severe front-end damage, but there was no word on injuries to anyone in the vehicle.
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Authorities have shut down the area to traffic.
An investigation is underway on what led to the collision.