It happened shortly before 1:30 p.m. Friday in the 2700 block of North Broad Street.
Police say the 30-year-old victim was stabbed in the head, neck and back several times.
The woman was rushed to Temple University Hospital.
Police say a person of interest was taken into custody in the area of 15th and Market.
The name of the woman who was stabbed has not been released.
Stay with Action News and 6abc.com as this story develops.