It happened around 12:25 a.m. on the 1400 block of South Vogdes Street.
Police said both were shot outside of their house by a person known to the family.
Husband and wife shot in front of children in Southwest Philadelphia, police say
They were both taken to Penn Presbyterian Hospital in critical condition. Police said the 42-year-old man subsequently died there.
According to investigators, an argument preceded the shooting.
Police continue to investigate the incident.
**This story is developing. Check back with 6abc.com for updates.***