It happened around 9 p.m. on the 2600 block of South 68th Street.
Police tell Action News that a 19-year-old male driver flipped the vehicle after a gunman opened fire.
The 19-year-old man died, police said.
The passenger, identified as a 20-year-old woman, is listed in stable condition at an area hospital after being shot once in the leg.
No arrests have been made.
Anyone with any information is asked to call police at 215-686-TIPS.