The fire was reported around 10 a.m. Sunday on the 2200 block of Fitzwater Street.
There were four people inside the home at the time.
A man in his 30s is suffering from smoke inhalation; a 73-year-old man is suffering from burns and smoke inhalation; and a 71-year-old man suffered burns to his left hand and head.
The fourth person, a 67-year-old man, was not injured.
The fire was placed under control in about an hour.
The cause of the fire remains under investigation.
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