It happened around 7:30 p.m. Sunday near 12th and South streets.
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Investigators say the 25-year-old father was getting out of his car when he was approached by a man he did not know.
They say the gunman then shot the victim once in the neck in front of his children and a woman.
There is no word of a struggle, or even an argument, between the suspect and victim.
The family of four ran to a nearby vape shop for help. A book bag belonging to one of the children was left on the street.
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The father was taken to Jefferson University Hospital and is in stable condition.
The gunman remains on the loose.
Anyone with any information is asked to call police at 215-686-TIPS.
Gunman shoots father in neck on South Street
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