The shooting happened just after 4:30 p.m. near 62nd Street and Elmwood Avenue.
Police say a 20-year-old man was shot in the head and killed. The second victim, a 33-year-old man, was shot in the stomach.
Both victims were taken to Penn Presbyterian Hospital, officials say. The 33-year-old man, whose identity remains unknown, remains listed in critical condition.
There is no word yet on any possible arrest or what the motive may have been, officials say.