The incident occurred in the 2600 block of North Napa Street around 10 a.m. Sunday.
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Police say a 56-year-old man was shot once in the thigh.
The second victim, a 55-year-old woman, was shot once in the torso.
Both victims are currently hospitalized in critical condition at Temple University Hospital.
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No arrests have been made.
Anyone with any information is asked to call police a 215-686-TIPS.