The difference now, Toomey said, is that the Senate and White House are controlled by the same party, so there is no reason now to wait until after the Nov. 3 election, just six weeks away.
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"When divided government creates tension between the two organs responsible for filling a position on the Supreme Court, it is completely justifiable to leave open a vacancy until the voters have had a chance to speak," Toomey said in a statement.
Trump said he is obligated to pick a nominee as soon as possible to replace the liberal Justice Ruth Bader Ginsburg, who died Friday.
WATCH: What's next for the Supreme Court? McConnell says Senate will vote on replacement
After RBG's death, what happens with the Supreme Court vacancy?
Democrats says Ginsburg's seat should not be filled until after voters pick between Trump and Democrat Joe Biden and the winner is sworn in.
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In 2016, Toomey supported the decision to put off consideration of Obama's nominee, Merrick Garland, nominated in March to replace the late Justice Antonin Scalia.
Ultimately, Trump made the pick.