Takiya Holmes, 11, was struck by a stray bullet to her right temple Saturday night in Chicago.
Holmes was pronounced dead by doctors early Tuesday morning, but had been kept on life support for about four hours so that her organs could be used for transplants, family members confirmed.
One of her kidneys went to her cousin Darvese Monson, who is an advocate for kidney awareness.
Antwan C. Jones, 19, has been charged in Holmes's murder. He was aiming at people who were selling marijuana in a spot that he and others believed belonged to them, Cook County prosecutors said.
The Sun-Times Media Wire contributed to this report.