The incident happened inside a private residence just off campus early Saturday morning on the 1200 block of North Broad Street.
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Police are asking students to be aware of their surroundings.
"I wouldn't feel comfortable walking down these blocks," said Sabrina Williams, who lives in the area.
"It's hard. I feel like I can't walk by myself anywhere. I feel like I always need to be with someone, especially a guy," said Hailey Sharp, who is frequently on campus with her boyfriend, who is a Temple University student.
News of the off-campus sexual assault has rattled some as students got a notification about the assault from the police Saturday.
"We get notifications a lot about more people getting robbed or gunshots but never anything about sexual assault before," said sophomore Jamal Evans.
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Temple University Police also reminded students of the escort service, which is available between 4:00 p.m. and 6:00 a.m. for students who don't want to walk alone.
"I usually don't go out at night by myself. If I do go out at night, I usually go with somebody else," said sophomore Dharma Grasso.
Police encourage students to walk in well-lit, well-traveled areas.
Anyone with information is asked to contact Temple University Police at 215-204-1234.