It happened before 2 p.m. Wednesday in the westbound lanes.
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Police tell Action News the driver of a box truck lost control and crashed.
Video from Chopper 6 showed the truck in a wooded area alongside the highway.
RAW VIDEO: Crash on AC Expressway
At least two people in the truck were injured.
A medical helicopter has been dispatched to the scene.
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Stay with Action News and 6abc.com for more information as it becomes available.
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