It happened around 8:30 p.m. at a vacant home on the 700 block of Southard Street.
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Chopper 6 was over the scene as flames were shooting through the roof of the two-and-one-half-story structure.
Chopper 6 over massive 3-alarm fire in Trenton
The deputy fire chief tells Action News it appears to have been a "hoarder" house, which made it nearly impossible for firefighters to get inside.
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It took crews about two hours to get the fire under control.
No injuries have been reported.
The cause of the fire remains under investigation.