In Philadelphia, the United Ukrainian American Relief Committee has been busy collecting items for those in need.
"It's going to get into a crisis mode," said Motrja Watters of the organization.
On Monday night, Watters took Action News inside their building where boxes and boxes of items have been collected.
They're in need of everyday items to medical supplies.
"We need diapers. We need briefs. We need hygiene products. Anything from bandages, needles and syringes," said Watters.
"It's going to Poland. It's going to clear Customs in Poland. And from Poland, it's going to go to Ukraine," said Watters.
They are planning to ship items out around 1 p.m. Wednesday.
Below is a list of other organizations responding to the crisis in Ukraine.
People in Need
People in Need is providing humanitarian aid to more than 200,000 people on the ground in Ukraine. The Czech organization will "provide mainly the most basic needs according to the currently developing situation ... [like] cash assistance, food aid [and] hygiene items" in its first phase of support, according to its website.
People in Need also pledged to support countries experiencing an influx of Ukrainian refugees.
WATCH: Ukrainians leave country as fighting breaks out with Russian forces
Ukrainians leave country as fighting breaks out with Russian forces
Red Cross
The International Committee of the Red Cross has had a presence in eastern Ukraine for years to deliver assistance to those affected by the Russian conflict following the annexation of Crimea, according to its website.
The organization is "vowing continued support for the at-risk families in the region" amid growing concerns over displacement, mass casualty and destruction.
The American Red Cross, in particular, is "sending 30 trained staff to Europe to support emergency communication needs of U.S. military members."
Ukrainian National Women's League of America
Sofika Zielyk, a member of the Ukrainian National Women's League of America, said the organization is in "full crisis mode" to respond to the invasion.
"This is a war that everybody has to look at and try to help," she told ABC News.
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Donations so far have benefited hospitals in the eastern Ukrainian cities of Kharkiv and Luhansk, the organization posted on its Facebook page.
UNICEF
UNICEF is working to assist children and families in Ukraine by making sure their critical needs are met, like access to safe water, health care, education and protection, according to its website.
The organization already has 10 child protection case management mobile teams stationed in the country's east to provide "psychosocial care to children traumatized by the chronic insecurity" of the conflict with Russia.
AIRBNB
Airbnb.org and Airbnb are today announcing that Airbnb.org will offer free, short-term housing to up to 100,000 refugees fleeing Ukraine.
UNITED HELP UKRAINE
United Help Ukraine (UHU) is working to provide individual first aid kits (containing blood-stopping bandages and tourniquets) and other emergency medical supplies to the front lines.
In addition, UHU is also cooperating with other emergency response organizations to prepare humanitarian aid for civilians that might be directly affected if Russian forces attack.
The Associated Press contributed to this report.