Authorities say the female victim's body was discovered in a residential rear alley along the 7000 block of Greenwood Avenue, near Church Lane.
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Paramedics were initially called to the scene around midnight Monday for a medical response.
They arrived to find the unidentified body in an alley area behind a row of twin homes, just steps away from a playground.
Police said the medical examiner determined the body is that of a white woman and ruled the death suspicious.
Additional testing will need to be done to determine the cause of death, but there was no evidence of blunt force trauma.
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Investigators said they don't currently have any missing persons reported in Upper Darby.
Anyone with information is asked to call police.