Upper Dublin Township police responded to a reported shooting inside a home along the 3200 block of Pebblewood Lane just before 12:30 a.m.
Officers found a 41-year-old man suffering from a gunshot wound to the arm.
He was taken to an area hospital and placed in stable condition.
Police say the man's 46-year-old wife is now in custody.
No formal charges have been filed at this time.