Beginning at 7 p.m., the ramp will be closed for 25 days for structural repairs and resurfacing operations.
The construction is part of PennDOT's $103.6 million project to rehabilitate the Chestnut Street Bridge and seven other structures nearby, including this ramp.
Drivers will be directed west on Walnut Street, then left on 38th Street to University Avenue, then south to 34th Street to the eastbound ramp.
PennDOT says if all goes according to plan, the ramp will reopen June 14.