Police said the driver of a Nissan Sentra was speeding and lost control near West Erie Avenue and North 2nd streets around 2 a.m. Wednesday.
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The driver left the road and hit a least three concrete barriers outside of the Verizon Warehouse building.
Police found the car's transmission nearly 75 feet from the Nissan; other car parts were strewn for half a block.
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The male driver was taken to the hospital in serious condition.
No other injuries were reported.