It happened around 5 p.m. Sunday on the 5500 block of Chancellor Street.
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Authorities say a 13-year-old girl tried to stop two young women from shoplifting when an altercation ensued.
That's when one suspect allegedly deployed the pepper spray.
The 13-year-old and a 1-year-old were sprayed inside the store. Both were taken to the hospital for treatment.
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Police are still searching for the suspects.
Anyone with information is asked to call police at 215-686-TIPS.