The shooting happened around 8:45 p.m. on the 4300 block of Parrish Street.
Police say two teens were sitting on a car when they heard shots and started to run.
Both then realized they were wounded. A 16-year-old male was shot in the right thigh, and a 15-year-old girl was also shot in the right thigh.
Both are listed in stable condition at Penn Presbyterian Medical Center.
No arrests have been made at this time.