The shooting happened just after 4 p.m. Saturday on the 600 block of South 57th Street.
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Police said a 51-year-old man and a 53-year-old man were both shot in the left leg.
They were both transported by police to Penn Presbyterian Medical Center in stable condition.
A woman believed to be in her 30s was also shot in the right cheek, officials say.
She was also taken to Penn Presbyterian in stable condition.
Police said all three shooting victims were innocent bystanders caught in the crossfire.
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A total of 58 rounds were said to have been fired during the shooting.
Neighborhood resident Francina Wall's husband Shawn was one of the victims struck by gunfire.
"I was pulling bags out of the car, and next thing you know, I heard something that sounded like firecrackers," Francina Wall said. "Next thing I know, my husband said, 'Fran, get down!' And I'm like, 'What?!' And he said, 'Get down!' And that's when I heard the shots."
Wall said she and her husband, were just getting out of the car in front of their home on South 57th Street when the shots began.
"All I know was I heard my husband saying, 'Get down! Fran they're shooting! Get down!' And I did, and unfortunately for my husband, he got hit. He got hit in the leg," she added.
Police said a witness saw two or three men get out of a red car and start shooting.
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Wall said she is grateful for the police who quickly picked up her husband and took him to the hospital.
No weapons were recovered at the scene, officials said.
There is no word on any arrests made at this time.
Tips can be made anonymously by calling (215) 686-TIPS.