Witness video shows flames shooting through the roof of the home.
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The house on Mary Street near Belmont Avenue caught fire at around 2 a.m. Sunday.
Action News is told a man was trapped in a first-floor apartment.
Elsmere police officers rushed in to help rescue him.
The man is critically injured, being treated for burns and smoke inhalation.
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The officer's condition has not been released.
Two people living in a second-floor apartment escaped unharmed.
The cause of the fire is still being investigated.