The incident happened just before 8 p.m. on the 1300 Block of North Claymont Street.
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Police say they located a 41-year-old Rasheed White suffering from gunshot wounds.
He was transported to a nearby hospital, where he later died from his injuries.
So far, no arrests have been made.
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Anyone with information is asked to contact police or Detective Steven Bender at (302) 576-3621.