The incident happened just before 8 p.m. on the 1300 Block of North Claymont Street.
Police say they located a 41-year-old Rasheed White suffering from gunshot wounds.
He was transported to a nearby hospital, where he later died from his injuries.
So far, no arrests have been made.
Anyone with information is asked to contact police or Detective Steven Bender at (302) 576-3621.