Authorities said the victims were riding around 1:30 a.m. Saturday when they lost control of the ATV at the intersection of Fleming Pike and Union Avenue.
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The vehicle slammed into a trailer; both were ejected from the ATV.
Police said the man was found unconscious and the woman suffered several fractures.
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They were taken to Cooper University Hospital.
There is no word on what caused them to lose control of the ATV.