Officers were called to the 1400 block of West Roosevelt Boulevard at about 5:40 a.m. for a crash.
According to investigators, a white vehicle was heading westbound when it hit a woman who was lying on the road.
Officers said the vehicle left the scene and was last seen continuing west on Roosevelt Boulevard.
A 21-year-old woman was taken to Temple University Hospital where she died about an hour later.
The investigation is ongoing and anyone with information is asked to call police.