It happened around 9:25 a.m. Tuesday on Frankford Avenue.
Police said the driver of a maroon GMC Acadia, a 25-year-old man, was going the wrong way on Frankford Avenue.
His GMC struck two parked cars and slammed head-on into a black Nissan Versa.
The 61-year-old woman driving the Versa was pronounced dead at the scene.
The wrong-way driver was taken to Einstein Medical Center for treatment.
There has been no word on any charges.
The name of the 61-year-old woman has not been released.