The first one happened near the intersection of 52nd Street and Lancaster Avenue in the city's Parkside section. An unidentified man was shot dead there around midnight.
A few hours later another man was shot dead inside a car just before 3 a.m. Friday near the intersection of Washington and Crittenden in the Germantown section.
We're told the suspect was seen leaving the scene.
You can get the latest crime statistics from the Philadelphia Police by CLICKING HERE for the force's crime data mapping site.