"The project is a fun idea which broadens the appeal of The Beatles and their music. I like people having the opportunity to get to know the music from the inside out," Paul McCartney said in a statement.
The game will not be titled "Rock Band," but will work with the existing instruments - a guitar, drums and microphone.
Game developers also plan to introduce a keyboard, which would be a first in the music game market.
"That is the plan," said Marty Bandier, chief executive of Sony/ATV, a joint venture between Sony Corp. and trusts benefiting Michael Jackson, which owns the copyright on Beatles songs by John Lennon and McCartney.
"I would say that there will be interactive performances of The Beatles' music as well as new dimensions that you haven't seen from us before," Harmonix Chief Executive Alex Rigopulos told reporters Thursday.
The video game has become a key and profitable market for established musical acts such as Metallica and Aerosmith to expose their music to a new generation of fans; some bands have even debuted their music via video games.
"The Beatles continue to evolve with the passing of time and how wonderful that The Beatles' legacy will find its natural progression into the 21st century through the computerized world we live in," said Beatles drummer Ringo Starr in a release. "Let the games commence."
Grammy winner Giles Martin, son of The Beatles' producer, George Martin, will serve as music producer, with input from McCartney, Starr, Yoko Ono and Olivia Harrison.
The game will feature sampling of music and imagery from throughout the band's career, from "Please Please Me" (1963) through "Let It Be" (1970).
Talks on the game between Viacom Inc.'s MTV and Harmonix units, master recordings owner EMI Group PLC and The Beatles' company, Apple Corps Ltd., have been in the works for almost a year and a half, said Paul DeGooyer, MTV's senior vice president of electronic games and music.
But the news doesn't mean that long-awaited digital downloads of the band's music would be available anytime soon.
"We're still working out the details," said Jeff Jones, Apple Corps' chief executive. "We have no announcement to make."