It was the final stop on a seven-game, 12-day road trip which began Nov. 18 in Los Angeles against the Lakers. All three of Chicago's road wins came during this stretch.
Elton Brand had 21 points and 12 rebounds, and Thaddeus Young added 17 points for the reeling Sixers, who have lost four straight to fall to 7-10. Andre Miller had 15 points and 10 assists, and Willie Green chipped in with 12 points.
Philadelphia scored a season-low 78 points in a 24-point loss at Boston on Friday and has been held below the 100-point mark in seven consecutive games.
The Bulls held a 71-66 lead late in the third before running off 12 straight points to take an 83-66 advantage at the end of the quarter. Rose had six of the 12 points, including a high-flying, one-handed dunk with 32 seconds remaining.
After a 3-pointer by Hughes gave the Bulls a 92-73 lead with 7:21 left, the fans booed and a large throng of them began to vacate the arena. When the game ended, the boos careened down once again.
The Sixers led by as many as 15 points in the first half before Chicago went on a 14-0 run to cut the lead to 41-40 on a basket by Luol Deng with 4:57 remaining.
Philadelphia finished the half strong and held what would wind up being a short-lived 55-52 lead.
Notes: Brand was originally selected by Chicago with the top pick in the 1999 draft. Brand spent two seasons with the Bulls and seven with the Los Angeles Clippers before signing with the Sixers as a free agent in July. Young had 11 points in the first quarter for the Sixers. The announced crowd was 13,561, but there were pockets of empty seats throughout the 20,000-plus seat arena.