Two officers fired multiple times and fatally wounded the man when he refused commands to drop the gun, raising it toward them, police said.
"Unfortunately this man lost his life. But the officers responded quickly and prevented any other injuries to staff or patients," police spokesman Todd Rasmussen said.
A nurse supervisor summoned Henderson police after the man "made some suicidal statements and said he had a gun," Rasmussen said.
About 30 people were in the emergency room at the time, police said in a statement. The emergency room remained closed after the shooting but most of the hospital was open.
The man's name was not immediately released.
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