Vick spent most of the game on the sideline watching youngsters Kevin Kolb, LeSean McCoy and DeSean Jackson lead the Eagles to a one-sided victory.
McCoy ran for a touchdown. Kolb ran for one and threw for two others, including one to Jackson, who had a career-best 149 receiving yards.
Vick could only cheer them on. His 11 plays, which included seven handoffs, resulted in a net of 30 yards.
Those are humble numbers for a player who was one of the most feared weapons in the league before his legal troubles.
Vick, who served 18 months in prison on a federal dogfighting charge, took the field on the second play from scrimmage. He lined up at wide receiver, went in motion and had a handoff faked to him, then watched as McCoy lost a yard on a carry.
Some in the crowd rose to give Vick a standing ovation, but he was back on the sideline so quickly - after one play - that many fans at Lincoln Financial Field didn't seem to notice him.
A Pro Bowler in three of his six seasons with the Atlanta Falcons, Vick went from a hero to a disgrace in 2007 when his association with a dogfighting ring was announced by federal authorities.
Before the game, a group of about 25 protesters gathered at the northeast entrance to the stadium, holding signs saying, "Vick is sick" and "Ethics over athletics." As fans walked by, some began chanting Vick's name and a few shouted insults at the protesters or yelled at them to go home. Philadelphia police stayed close to keep an eye on things.
The only play of note for Vick in the opening half was his second from scrimmage. Taking a shotgun snap, Vick ran an option keeper to the right and gained 7 yards, drawing a cheer from the crowd.
The fleet-footed Vick, who gained 1,000 yards rushing in 2006, got a chance to throw his first pass on the same series on a first-and-goal from the Chiefs 5. However, it went out of the end zone as he took a big hit.
Vick took a shotgun snap on the Eagles' third series and handed off to McCoy for an 11-yard gain.
Kolb was not on the field for any of the six shotgun snaps Vick took in the first half.
Vick's other plays were a bounced pass attempt to Jason Avant, a handoff to receiver Jeremy Maclin and a handoff to McCoy for 5 yards.
He spent the rest of the time standing on the sideline, handing his helmet to an equipment man and taking a visor in return.
Vick played four plays in the second half, handing off each time.
At the end of the game, he looked into the crowd and waved to someone and then hugged an Eagles assistant. He was the last player on the field, staying to do a television interview.
Vick was released from prison in late July and signed a one-year deal for $1.6 million with an Eagles' option for a second year at $5.2 million. Commissioner Roger Goodell announced in early September that Vick, who played in two preseason games, would be eligible to play this week after sitting out the first two regular-season games.
Vick has called his dogfighting offenses "a horrible mistake" and vowed to crusade for animal rights.