Scott Clemmensen stopped 25 shots in his first start for Florida. Signed as a free agent in the offseason, he didn't start after Feb. 18 last season with New Jersey.
Arron Asham and Claude Giroux scored for Philadelphia. The Flyers have lost three straight after starting the season 3-0. Ray Emery, who has started every game in goal for Philadelphia, made 23 saves.
The Flyers played for the first time since a 3-2 shootout loss to Anaheim on Saturday night. They spent most of the week in South Florida and had a boat race Tuesday and a deep-sea fishing tournament Wednesday.
With David Booth in the penalty box for tripping, Dvorak scored on a breakaway for his second short-handed goal in two games. He grabbed a loose puck in the neutral zone after Chris Pronger failed to keep a Florida clearing attempt in the offensive zone. With Simon Gagne chasing him, Dvorak managed to flip a short forehand shot that went off Emery's stick.
Philadelphia led 2-1 until the final minute of the second period when Horton tipped Jordan Leopold's shot from the point while standing in front of the net.
Giroux had given the Flyers the lead at 12:14 of the second when his wrist shot sneaked through between Clemmensen's body and his left arm and barely crossed the goal line before defenseman Keith Ballard swiped it away. The goal was confirmed after video review.
Asham opened the scoring 6:35 into the game after James van Riemsdyk stripped the puck from Weiss in the Florida zone. Asham grabbed the loose puck to the right of Clemmensen and beat him with a backhander to the short side.
Philadelphia led 1-0 after the first 20 minutes and also hit the post twice in the period.
Weiss redeemed himself by tying the game with a power-play goal at 6:49 of the second. He beat Emery with a wrist shot from the top of the right faceoff circle.
NOTES: The worst six-game start in Panthers history came in 2001-02 at 1-4-1. ... Dvorak extended his franchise record for most career short-handed goals with his 14th. ... C Dominic Moore made his debut with the Panthers. He was signed as a free agent on Oct. 5, but his arrival was delayed because of visa issues. ... Florida coaches and staff members are wearing commemorative Hockey Fights Cancer to support cancer awareness. ... Flyers LW Simon Gagne, who scored 34 goals last season, remains scoreless in 2009-10. ... Van Riemsdyk returned to the lineup after missing two games because of concussion symptoms.