The accident occurred in the southbound lanes of Route 55, 3 miles south of Route 49, around 11:30 Thursday morning.
Rescue workers were called out to the scene. When they arrived they found the van had overturned into a wooded area.
The guard driving and two prisoners were taken by ground to Regional Medical Center in Vineland with minor injuries. Another guard was flown to flown to Cooper University Hospital with severe injuries.
The roadway was shut down for a little over an hour while the scene was cleared.