The Flyers had a chance in the game's closing seconds, but Jeff Carter's short-handed breakaway attempt was stopped by Rusk. Philadelphia is 1-1 in shootouts.
Philadelphia (4-2-1) snapped a three-game losing streak after starting the season 3-0 for the first time since 1998-99. Boston dropped to 4-5-0.
The Bruins, who beat Nashville 3-2 on Wednesday night, are playing without two injured stars, Marc Savard and Milan Lucic.
Philadelphia's Ray Emery stopped 23 shots.
Matt Hunwick smacked a wrist shot from just inside the blue line, giving Boston a 2-1 lead. Philadelphia's Darroll Powe answered 1:05 later. Ole-Kristian Tollefsen's shot from the blue line hit the post, and Powe flicked Dan Carcillo's behind-the-net pass past goalie Tuukka Rask's glove for the tie.
Philadelphia's Aaron Asham's slap shot from the right faceoff circle made it 3-2 with 6:54 left in the second, but Steve Begin knocked in a rebound to tie it.
Chris Pronger's one-timer opened the scoring for the Flyers. Derek Morris' power- play goal late in the first period evened the score.
NOTES: Philadelphia Phillies' pinch-hitter Matt Stairs attended the game. ... Carter played in his 221st straight regular-season game. ... Tollefsen had his first career two-point game.